subcutaneous reaction of rat tissues to nanosilver coated gutta-percha
نویسندگان
چکیده
introduction: gutta-percha (gp), is a neutral and non-toxic material. the aim of this animal study was to compare the biocompatibility of nanosilver coated gp (ns-gp) with conventional gp in subcutaneous tissues in a rat model. methods and materials: conventional gp and ns-gp were subcutaneously implanted in the backs of 20 male wistar rats ( n =10). a control animal was assigned for each trial period. ten animals were sacrificed after 7 and 30 days and light microscopic evaluation of tissue reaction to ns-gp ( n =20) and conventional gp ( n =20) was accomplished. the mann-whitney u, wilcoxon signed ranks, fisher exact, and mcnemar tests were used for statistical analysis of the data. results: after 7 days, inflammation was moderate and mild for ns-gp and conventional gp, respectively ( p <0.001). after 30 days, no inflammation was discernible in conventional gp. however, mild inflammation was reported for ns-gp ( p <0.001). regarding inflammatory cell type, there was a significant difference between two experimental groups at both times ( p <0.001). conclusion: inflammation decreased over time in both groups. fibrous connective tissue, a representative of healing and control of inflammatory process, surrounded both test materials. ns-gp was biocompatible and might be a reasonable endodontic obturation material.
منابع مشابه
Subcutaneous Reaction of Rat Tissues to Nanosilver Coated Gutta-Percha
INTRODUCTION Gutta-percha (GP), is a neutral and non-toxic material. The aim of this animal study was to compare the biocompatibility of nanosilver coated GP (NS-GP) with conventional GP in subcutaneous tissues in a rat model. METHODS AND MATERIALS Conventional GP and NS-GP were subcutaneously implanted in the backs of 20 male Wistar rats (n=10). A control animal was assigned for each trial p...
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متن کاملcomparing microleakage in root canals obturated with nanosilver coated gutta-percha to standard gutta-percha by two different methods
introduction: favorable apical seal of root filling materials is a crucial factor for a successful root canal treatment. the aim of this in vitro study was to compare bacterial and dye microleakage of two root canal filling materials including standard gutta-percha and nanosilver coated gutta-percha, and to evaluate the agreement between results of these two methods . materials & methods: fifty...
متن کاملThe thermomechanical properties of gutta-percha. I. The compressibility of gutta-percha.
Sample wafers of compounded dental gutta-percha and uncompounded dental-grade gutta-percha were compression tested to 20,000 pounds in uniaxial and triaxial systerns. Unrestrained flow in the uniaxial series prevented development of stress levels sufficient to produce molecular compression. Negligible molecular compression did occur in the triaxial series but only above a stress level of approx...
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عنوان ژورنال:
iranian endodontic journalجلد ۱۲، شماره ۲، صفحات ۱۵۷-۱۶۱
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